We are often asked, “what is biobanking?” or, “how does it work?”. This page aims to answer those questions – expand each one to learn more.
Biobanking explained
What are biobanks?
A biobank is a place that collects, processes, stores and distributes biological samples and related health data for scientific projects. These samples are voluntary and always stored with the consent of the participant.
Biobanks are important partners for research and medical progress. By analysing these samples, scientists can better understand how diseases develop, improve diagnosis and create more targeted treatments. This makes biobanks essential in advancing medical research and also personalised medicine that aims to tailor treatment to each patient.
Although participants may not benefit personally from their contribution, biobank-supported research has already led to major medical breakthroughs. By contributing to biobanks, patients and participants help accelerate discoveries that will benefit many people in the future.
What do human biobanks store?
Biobanks store biological samples, such as blood, tissue, cells, DNA or other biological materials. These samples are often stored along with data that tells its story such as sample type, its storage temperature and related medical information about the participant, for example health data linked to diagnosis or treatment.
The samples are carefully processed and preserved under controlled conditions to keep them usable for answering different research questions over a long time. Together, these biological samples and data are made available for medical research to support better diagnostics and treatments.
To preserve their quality, samples are stored in different ways depending on the material. Some are kept in freezers at very low temperatures while others, like tissue pieces, can be preserved in formalin and paraffin, substances that keep them stable at room temperature for a long time. These storage methods ensure that the samples remain high-quality for future medical studies.
How does a biobank work?
Samples are registered, prepared and stored using specialised equipment. They are continuously monitored, protected and there are procedures in place to ensure their safety in event of an emergency such as a longer blackout – biobankers really care about looking after these collections.
Researchers submit requests to use samples, which are reviewed to ensure the samples are available, suitable and can be released under ethical and legal standards. Ethics committees at each biobank or biobank institution apply strict data protection and ethics rules to safeguard participants’ rights and privacy. When a sample is used for research, the participant’s data is coded to protect their identity.
Great professional care is taken with a sample. Highly trained staff, including technical specialists and quality management experts, manage all areas of biobank operations. Combining advanced technology, procedures and strong ethical oversight enables biobanks to provide such high-quality samples and data.
There are different kinds of biobanks
They can be classified according to different criteria. Depending on the orientation of the biobank, a distinction is usually made between clinical, population-based and non-human biobanks.
Clinical biobanks
Clinical biobanks collect, process, store and distribute blood, tissue or other biological samples from patients and participants and can link them to the associated clinical information. Scientists and doctors can obtain important information about different diseases from these samples and data and derive new diagnostic and therapeutic approaches.
Many clinical biobanks are integrated into university hospitals as so-called centralised biobanks. In centralised biobanks, almost all biological sample collections of a university hospital are stored in one place.
Explore more
Meet Prof. Udo Jeschke (University Hospital Augsburg) who will tell you more about his current research on Gestational Diabetes and HELLP syndrome. The full World Health Day coverage is here.
Population-based biobanks
Population-based biobanks collect biological samples and health data from large groups of people. They might be used to create a general picture of a population or focus on a specific group, disease or condition.
Researchers use them to study how genetics, lifestyle, social or economic or environmental factors affect health and the development of common diseases. By providing a wide range of information, population-based biobanks help scientists understand health trends, find risk factors and make important discoveries about diseases like cancer, diabetes and heart disease.
Explore more
Meet Dionysis and Anna, a biobank researcher and a participant in the Cyprus population cohort project – CYPROME. They describe the purpose of the project and what it is like to take part. The full story is part of our World Health Day coverage.
Non-human biobanks
Non-human biobanks house biological samples and related data from non-human sources, such as animals, plants, soil and microbes. They support research in areas such as veterinary medicine, agriculture, ecology, wildlife conservation, environmental studies and evolutionary biology.
All of these play a key role in the One Health approach. Although the samples are non-human, research using these resources sometimes has direct implications for human health, from understanding the way diseases work to improving environmental and agricultural outcomes.
Explore more
Meet Dr. Eva Maria Hodel, BEready Project Manager, who discusses a collection of both human and animal participant samples for a pandemic preparedness study. The full story is part of our One Health coverage.
What is BBMRI-ERIC’s role in this?
BBMRI-ERIC is the European research infrastructure (RI) for biobanking and biomolecular resources, one of the largest RIs in the health and life sciences. BBMRI-ERIC operates as a network of National Nodes and partner biobanks, working together to support medical research and the advancement of medicine. It does so by providing expertise and services to its Member States on a non-economic basis and facilitates access to the collections of partner biobanks and biomolecular resources.
BBMRI-ERIC works to connect biobanks and researchers across Europe to use samples and data collected for the benefit of human health. We help researchers find the samples and data they need by supporting the use of biobanks that meet well-defined quality standards, ensuring all samples and data are ethically and legally compliant.
We assist biobanks with visibility, quality development and usability and advise them on ethical and legal matters, such as the European regulatory framework. We help people by taking responsibility for turning high-quality research into discoveries that improve health.
Explore more
Meet BBMRI-ERIC’s Chair of the Patient and Citizens Pillar, a group of patient organisations that oversees best ways to work with biobank participants. He describes the importance of involving patients and the public in biobanking at all stages of collection and research.
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